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Article

Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field.

Leukemia - 1 Nov 2021

Falini Brunangelo, Sciabolacci Sofia, Falini Lorenza, Brunetti Lorenzo, Martelli Maria Paola

Abstract excerpt

Mutations of Nucleophosmin (NPM1) are the most common genetic abnormalities in adult acute myeloid leukaemia (AML), accounting for about 30% of cases. NPM1-mutated AML has been recognized as distinct entity in the 2017 World Health Organization (WHO) classification of lympho-haematopoietic neoplasms. WHO criteria allow recognition of this leukaemia entity and its distinction from AML with myelodysplasia-related...

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Identifiers

PMID: 33879827
DOI: 10.1038/s41375-021-01222-4
PMCID: PMC8056374

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