Article
Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient-specific NPM1 mutations.
American journal of hematology - 1 Dec 2010
Dvorakova Dana, Racil Zdenek, Jeziskova Ivana, Palasek Ivo, Protivankova Marketa, Lengerova Martina, Razga Filip, Mayer Jiri
Abstract excerpt
Nucleophosmin (NPM1) mutations in exon 12 are the most common genetic alternation in cytogenetically normal AML (CN-AML). Although mutation types A, B, and D represent the majority of cases, rare mutation variants of the NPM1 gene in individual patients do occur. In this study, we have evaluated a novel, DNA-based real-time quantitative polymerase chain reaction (RQ-PCR) for the detection of three of the most...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.