NPM1-mutated acute myeloid leukemia of monocytic or myeloid origin exhibit distinct immunophenotypes.

doi:10.1016/j.leukres.2013.03.009

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Article

NPM1-mutated acute myeloid leukemia of monocytic or myeloid origin exhibit distinct immunophenotypes.

Leukemia research - 1 Jul 2013

Liu Yan-Rong, Zhu Hong-Hu, Ruan Guo-Rui, Qin Ya-Zhen, Shi Hong-Xia, Lai Yue-Yun, Chang Yan, Wang Ya-Zhe, Lu Dan, Hao Le, Li Jin-Lan, Li Ling-Di, Jiang Bin, Huang Xiao-Jun

Abstract excerpt

Acute myeloid leukemia with mutated nucleophosmin (NPM1m+AML) is a heterogeneous entity. We investigated whether NPM1m+AML with monocytic or myeloid differentiation have distinct immunophenotype. The study included 160 NPM1m+AMLpatients and 178 AML patients without NPM1 mutation and recurrent cytogenetic abnormality (NPM1wt-AML). We analyzed the immunophenotype by flow cytometry. NPM1 mutation was detected by...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Antigens, CD
Child
Child, Preschool
Chromosome Aberrations
Female
Flow Cytometry
HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunophenotyping

Leukemia, Myeloid, Acute

Male

Middle Aged

Monocytes

Mutation

Source

Open in PubMed

Identifiers

PMID: 23601747
DOI: 10.1016/j.leukres.2013.03.009

Genes

NPM1

Provenance

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