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Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia.

Protein and peptide letters - 1 Apr 2013

Agrawal Vaidehi, Woo Jung Hee, Borthakur Gautham, Kantarjian Hagop, Frankel Arthur E

Abstract excerpt

Red blood cell (RBC) encapsulated L-asparaginase is a novel therapeutic for the treatment of asparagine auxotrophic malignancies. The enzyme-loaded red blood cells function as bioreactors to deplete bloodstream substrate. This delivery system provides improved pharmacodynamics with protection from circulating proteolytic enzymes and avoidance of early liver or renal clearance. The "drug" is manufactured with ABO...

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PMID: 23016580

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ABO

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Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia.PMID 23016580Read ↗

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