Article
Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study.
Leukemia - 1 Sept 2008
Appel I M, Kazemier K M, Boos J, Lanvers C, Huijmans J, Veerman A J P, van Wering E, den Boer M L, Pieters R
Abstract excerpt
L-asparaginase is an effective drug for treatment of children with acute lymphoblastic leukemia (ALL). The effectiveness is thought to result from depletion of asparagine in serum and cells. We investigated the clinical response in vivo of 1000 IU/m(2) pegylated (PEG)-asparaginase and its pharmac...
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