Back to search

Article

Biogeneric native and polyethylene glycol-conjugated <i>E. coli</i> asparaginases for treating children with acute lymphoblastic leukaemia

2025-10-30

Abstract excerpt

Escherichia coli asparaginases (EcASNase) available for the treatment of children with acute lymphoblastic leukaemia (ALL) are largely of suboptimal quality in low-middle income countries (LMIC) and contribute to inferior outcomes. The pharmacokinetics, activity, and immunogenicity of a native (EcASNase) and a PEGylated ASNase (PEG-EcASNase) were analysed. Biogeneric EcASNase 10,000 IU/m 2 was administered intram...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ff0ccc79-ef00-5d71-bdd9-a994a54a07c7
DOI
10.1101/2025.10.28.25337165
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Biogeneric native and polyethylene glycol-conjugated <i>E. coli</i> asparaginases for treating children with acute lymphoblastic leukaemiaDOI 10.1101/2025.10.28.25337165
Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemiaSemantic proximity
Update on the Use of L-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic LeukemiaSemantic proximity
Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia.Semantic proximity
Mutations in asparaginase II from E. coli and implications for inactivation and PEGylation.Semantic proximity
<em>In Silico</em> Design of a Chimeric Humanized L-Asparaginase.Semantic proximity
Monitoring of Erwinia asparaginase therapy in childhood ALL in the Nordic countriesSemantic proximity
Studies on Deimmunization of Antileukaemic L-Asparaginase to have Reduced Clinical Immunogenicity--An in silico Approach.Semantic proximity
Comparative immunogenicity and structural analysis of epitopes of different bacterial L-asparaginasesSemantic proximity
Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.Semantic proximity
Asparaginase-Phage P22 Nanoreactors: Toward a Biobetter Development for Acute Lymphoblastic Leukemia TreatmentSemantic proximity
Mutations in Subunit Interface and B-cell Epitopes Improve Antileukemic Activities of Escherichia coli Asparaginase-IISemantic proximity
Recharacterization of EmAGA, a Potential Candidate for Novel ALL Therapeutics.Semantic proximity
Select a neighboring publication to make it the new centre.