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Asparagine Synthetase Chemotherapy

7 Apr 2006

Abstract excerpt

Modern clinical treatments of childhood acute lymphoblastic leukemia (ALL) employ enzyme-based methods for depletion of blood asparagine in combination with standard chemotherapeutic agents. Significant side effects can arise in these protocols and, in many cases, patients develop drug-resistant forms of the disease that may be correlated with up-regulation of the enzyme glutamine-dependent asparagine synthetase...

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PMID: 16756505
DOI: 10.1146/annurev.biochem.75.103004.142520

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