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Article

Efficient homologous recombination-mediated genome engineering in zebrafish using TALE nucleases.

Development (Cambridge, England) - 1 Oct 2014

Shin Jimann, Chen Jiakun, Solnica-Krezel Lilianna

Abstract excerpt

Custom-designed nucleases afford a powerful reverse genetic tool for direct gene disruption and genome modification in vivo. Among various applications of the nucleases, homologous recombination (HR)-mediated genome editing is particularly useful for inserting heterologous DNA fragments, such as GFP, into a specific genomic locus in a sequence-specific fashion. However, precise HR-mediated genome editing is still...

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Identifiers

PMID: 25249466
DOI: 10.1242/dev.108019
PMCID: PMC4197590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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