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Article

Radiation-induced HPRT mutations resulting from misrejoined DNA double-strand breaks.

Radiation research - 1 Jun 2008

Rothkamm Kai, Gunasekara Kut, Warda Salam A, Krempler Andrea, Löbrich Markus

Abstract excerpt

DNA double-strand breaks (DSBs) are the most severe lesions induced by ionizing radiation, and unrejoined or misrejoined DSBs can lead to cell lethality, mutations and the initiation of tumorigenesis. We have investigated X-ray- and alpha-particle-induced mutations that inactivate the hypoxanthine guanine phosphoribosyltransferase (HPRT) gene in human bladder carcinoma cells and in hTERT-immortalized human...

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Identifiers

PMID: 18494542
DOI: 10.1667/RR1185.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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