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Article

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.

Nucleic acids research - 1 Oct 2012

Phalke Sameer, Mzoughi Slim, Bezzi Marco, Jennifer Nancy, Mok Wei Chuen, Low Diana H P, Thike Aye Aye, Kuznetsov Vladimir A, Tan Puay Hoon, Voorhoeve P Mathijs, Guccione Ernesto

Abstract excerpt

p21 is a potent cyclin-dependent kinase inhibitor that plays a role in promoting G1 cell cycle arrest and cellular senescence. Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulated in the majority of tumours, including breast cancer. Here, we report that protein arginine methyltransferase 6 (PRMT6), a type I PRMT known to act as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

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Source

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Identifiers

PMID: 22987071
DOI: 10.1093/nar/gks858
PMCID: PMC3479215

Genes

PRMT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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