Article

The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle progression <i>via</i> Retinoblastoma protein

2018-05-30

Abstract excerpt

<h4>ABSTRACT</h4> RASSF6 is a member of the tumor suppressor Ras-association domain family (RASSF) proteins. RASSF6 is frequently suppressed in human cancers and its low expression is associated with poor prognosis. RASSF6 regulates cell cycle arrest and apoptosis and plays a tumor suppressor role. Mechanistically, RASSF6 blocks MDM2-mediated p53 degradation and enhances p53 expression. However, RASSF6 also indu...

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Literature Corpus work: 22ebd232-d4eb-5d49-843a-a54cd1f26978
DOI: 10.1101/334276

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