ZNF768 links oncogenic RAS to cellular senescence.

doi:10.1038/s41467-021-24932-w

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Article

ZNF768 links oncogenic RAS to cellular senescence.

Nature communications - 17 Aug 2021

Villot Romain, Poirier Audrey, Bakan Inan, Boulay Karine, Fernández Erlinda, Devillers Romain, Gama-Braga Luciano, Tribouillard Laura, Gagné Andréanne, Duchesne Éma, Caron Danielle, Bérubé Jean-Sébastien, Bérubé Jean-Christophe, Coulombe Yan, Orain Michèle, Gélinas Yves, Gobeil Stéphane, Bossé Yohan, Masson Jean-Yves, Elowe Sabine, Bilodeau Steve, Manem Venkata, Joubert Philippe, Mallette Frédérick A, Laplante Mathieu

Abstract excerpt

RAS proteins are GTPases that lie upstream of a signaling network impacting cell fate determination. How cells integrate RAS activity to balance proliferation and cellular senescence is still incompletely characterized. Here, we identify ZNF768 as a phosphoprotein destabilized upon RAS activation. We report that ZNF768 depletion impairs proliferation and induces senescence by modulating the expression of key cell...

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PMID: 34404770
DOI: 10.1038/s41467-021-24932-w
PMCID: PMC8370976

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