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CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?

14 Dec 2023

Abstract excerpt

Cyclin-dependent kinase inhibitor 1A (Cip1/Waf1/CDKN1A/p21) is a well-established protein, primarily recognised for its pivotal role in the cell cycle, where it induces cell cycle arrest by inhibiting the activity of cyclin-dependent kinases (CDKs). Over the years, extensive research has shed light on various additional mechanisms involving CDKN1A/p21, implicating it in processes such as apoptosis, DNA damage...

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PMID: 38139316
DOI: 10.3390/ijms242417488

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