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Article

AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation.

Cell death & disease - 15 Aug 2013

Jackstadt R, Jung P, Hermeking H

Abstract excerpt

Here we analyzed the function of the c-MYC-inducible basic helix-loop-helix leucine-zipper transcription factor AP4 in AP4-deficient mouse embryo fibroblasts (MEFs). Loss of AP4 resulted in premature senescence and resistance towards immortalization. Senescence was accompanied by induction of the cyclin-dependent kinase inhibitor-encoding genes p16, a known tumor suppressor, and p21, a previously described target...

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Identifiers

PMID: 23949224
DOI: 10.1038/cddis.2013.282
PMCID: PMC3763444

Genes

MYC

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Related research

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AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation.PMID 23949224Read ↗

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