Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p21 <sup>CIP1</sup> attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

26 Oct 2009

Abstract excerpt

p21(CIP1/WAF1) is a downstream effector of tumor suppressors and functions as a cyclin-dependent kinase inhibitor to block cellular proliferation. Breast tumors may derive from self-renewing tumor-initiating cells (BT-ICs), which contribute to tumor progression, recurrence, and therapy resistance. The role of p21(CIP1) in regulating features of tumor stem cells in vivo is unknown. Herein, deletion of p21(CIP1),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19858489
DOI: 10.1073/pnas.0910009106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p21 <sup>CIP1</sup> attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivoPMID 19858489Read ↗

CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?Semantic proximity Read ↗

p21 (WAF1/CIP1) Mediates the Growth Response to TGF-b in Human Epithelial CellsSemantic proximity Read ↗

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.Semantic proximity Read ↗

Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1Semantic proximity Read ↗

p21Cip1 nullizygosity increases tumor metastasis in irradiated mice.Semantic proximity Read ↗

Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model.Semantic proximity Read ↗

p21WAF1 and tumourigenesisSemantic proximity Read ↗

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.Semantic proximity Read ↗

Tamoxifen-stimulated growth of breast cancer due to p21 lossSemantic proximity Read ↗

Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cellsSemantic proximity Read ↗

Pro-survival roles for p21(Cip1/Waf1) in Non-Small Cell Lung CancerSemantic proximity Read ↗

p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.