New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy.

Abstract excerpt

Activation of the p53 signaling pathway by DNA-damaging agents was originally proposed to result either in cell cycle checkpoint activation to promote survival or in apoptotic cell death. This model provided the impetus for numerous studies focusing on the development of p53-based cancer therapies. According to recent evidence, however, most p53 wild-type human cell types respond to ionizing radiation by...

Topics

• Animals
• Cyclin-Dependent Kinase Inhibitor p21
• DNA Damage
• Humans
• Mutation
• Neoplasms
• Signal Transduction
• Tumor Suppressor Protein p53