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Article

Synergistic antibacterial activity and prevention of drug resistance of daptomycin combined with fosfomycin against methicillin-resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 6 Aug 2025

Ai Qin, Wang Sailan, Chen Ziyan, Zheng Shuai, Chen Zaixing, Zhang Na, Li Yaowen, Liu Huiping, Liu Yanyan, Li Jiabin, Huang Xiaohui

Abstract excerpt

The combination of daptomycin and fosfomycin is attracting attention due to the rising resistance observed in methicillin-resistant Staphylococcus aureus (MRSA). Most studies indicate that this combination exhibits synergistic or additive antimicrobial activity against MRSA. However, its capacity to prevent resistance remains uncertain. In this study, we first investigated the antibacterial effect of daptomycin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40530996
DOI: 10.1128/aac.01609-24
PMCID: PMC12327001

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