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Population Analysis of Daptomycin-non-Susceptible Methicillin-Resistant Staphylococcus aureus Reveals the Presence of Variants That Contribute to Daptomycin Resistance.

Current microbiology - 11 Jan 2024

Kanesaka Izumo, Yabuta Junya, Jitsukawa Tomotaka, Fujisaki Shingo, Morita Masahiro, Mikawa Takashi, Kanayama Katsuse Akiko, Takahashi Hiroshi, Ohno Akira, Kobayashi Intetsu

Abstract excerpt

In this study, population analysis (PA) of methicillin-resistant Staphylococcus aureus (MRSA), before and after long-duration daptomycin (DAP) treatment, was used to detect subpopulations with different susceptibilities to DAP and to verify the changes in the number of resistant cells. Furthermore, we aimed to characterize the bacteriology of the variants present in the non-susceptible cell subpopulation. A DAP...

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PMID: 38206417
DOI: 10.1007/s00284-023-03579-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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