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Article

The Zic2 gene directs the formation and function of node cilia to control cardiac situs.

Genesis (New York, N.Y. : 2000) - 1 Jun 2014

Barratt Kristen S, Glanville-Jones Hannah C, Arkell Ruth M

Abstract excerpt

The first molecular herald of organ asymmetry during murine embryogenesis is found at the periphery of the node in early-somite stage embryos. Asymmetric gene expression and calcium accumulation at the node occurs in response to a left-ward flow of extracellular fluid across the node, generated by motile cilia within the pit of the node and likely sensed by immotile cilia in the periphery of the node. The...

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PMID: 24585447
DOI: 10.1002/dvg.22767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Zic2 gene directs the formation and function of node cilia to control cardiac situs.PMID 24585447Read ↗

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