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Article

Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis.

Developmental biology - 15 Nov 2005

Bisgrove Brent W, Snarr Brian S, Emrazian Anoush, Yost H Joseph

Abstract excerpt

Recently, it has become clear that motile cilia play a central role in initiating a left-sided signaling cascade important in establishing the LR axis during mouse and zebrafish embryogenesis. Two genes proposed to be important in this cilia-mediated signaling cascade are polaris and polycystin-2...

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Identifiers

PMID: 16216239
DOI: 10.1016/j.ydbio.2005.08.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16216239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis.PMID 16216239Read ↗

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.Semantic proximity Read ↗

Disorders of left-right asymmetry: heterotaxy and situs inversus.Semantic proximity Read ↗

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Situs inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- mice.Semantic proximity Read ↗

The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.Semantic proximity Read ↗

Right-elevated expression of charon is regulated by fluid flow in medaka Kupffer's vesicle.Semantic proximity Read ↗

The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish.Semantic proximity Read ↗

Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia.Semantic proximity Read ↗

The genetic landscape of cardiovascular left-right patterning defects.Semantic proximity Read ↗

c21orf59/kurly Controls Both Cilia Motility and Polarization.Semantic proximity Read ↗

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