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Article

Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.

Gastroenterology - 1 Dec 2012

Villanueva Augusto, Alsinet Clara, Yanger Kilangsungla, Hoshida Yujin, Zong Yiwei, Toffanin Sara, Rodriguez-Carunchio Leonardo, Solé Manel, Thung Swan, Stanger Ben Z, Llovet Josep M

Abstract excerpt

BACKGROUND & AIMS: The Notch signaling pathway is activated in leukemia and solid tumors (such as lung cancer), but little is known about its role in liver cancer. METHODS: The intracellular domain of Notch was conditionally expressed in hepatoblasts and their progeny (hepatocytes and cholangiocytes) in mice. This was achieved through Cre expression under the control of an albumin and α-fetoprotein (AFP) enhancer...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Insulin-Like Growth Factor II

Share to Liver Neoplasms

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Source

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Identifiers

PMID: 22974708
DOI: 10.1053/j.gastro.2012.09.002
PMCID: PMC3505826

Genes

AFP
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.PMID 22974708Read ↗

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