Article
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.
Gastroenterology - 1 Mar 2017
Nault Jean-Charles, Couchy Gabrielle, Balabaud Charles, Morcrette Guillaume, Caruso Stefano, Blanc Jean-Frederic, Bacq Yannick, Calderaro Julien, Paradis Valérie, Ramos Jeanne, Scoazec Jean-Yves, Gnemmi Viviane, Sturm Nathalie, Guettier Catherine, Fabre Monique, Savier Eric, Chiche Laurence, Labrune Philippe, Selves Janick, Wendum Dominique, Pilati Camilla, Laurent Alexis, De Muret Anne, Le Bail Brigitte, Rebouissou Sandra, Imbeaud Sandrine, Bioulac-Sage Paulette, Letouzé Eric, Zucman-Rossi Jessica
Abstract excerpt
BACKGROUND & AIMS: Hepatocellular adenomas (HCAs) are benign liver tumors that can be assigned to molecular subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in β-catenin, or activation of inflammatory signaling pathways. We aimed to update the classification system for HCA and associate the subtypes with disease risk factors and complications. METHODS: We analyzed...
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