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Article

NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Oncogene - 1 Apr 2020

Luiken Sarah, Fraas Angelika, Bieg Matthias, Sugiyanto Raisatun, Goeppert Benjamin, Singer Stephan, Ploeger Carolin, Warsow Gregor, Marquardt Jens U, Sticht Carsten, De La Torre Carolina, Pusch Stefan, Mehrabi Arianeb, Gretz Norbert, Schlesner Matthias, Eils Roland, Schirmacher Peter, Longerich Thomas, Roessler Stephanie

Abstract excerpt

NOTCH receptor signaling plays a pivotal role in liver homeostasis and hepatocarcinogenesis. However, the role of NOTCH pathway mutations and the NOTCH target gene HES5 in liver tumorigenesis are poorly understood. Here we performed whole-exome sequencing of 54 human HCC specimens and compared the prevalence of NOTCH pathway component mutations with the TCGA-LIHC cohort (N = 364). In addition, we functionally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32055024
DOI: 10.1038/s41388-020-1198-3
PMCID: PMC7142020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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