Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features.

Journal of hepatology - 1 Mar 2021

Zhu Changyu, Ho Yu-Jui, Salomao Marcela A, Dapito Dianne H, Bartolome Alberto, Schwabe Robert F, Lee Ju-Seog, Lowe Scott W, Pajvani Utpal B

Abstract excerpt

BACKGROUND & AIMS: The hepatocyte Notch pathway is a pathogenic factor in non-alcoholic steatohepatitis (NASH)-associated fibrosis, but its role in hepatocellular carcinoma (HCC) is less well defined. Herein, we aimed to characterize the molecular and clinical features of Notch-active human HCC, and to investigate the mechanisms by which Notch affects NASH-driven HCC. METHODS: Using a 14-gene Notch score, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Hepatocytes

Share to Liver Cirrhosis

Share to Non-alcoholic Fatty Liver Disease

Share to Receptors, Notch

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 33038431
DOI: 10.1016/j.jhep.2020.09.032
PMCID: PMC7897246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features.PMID 33038431Read ↗

Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice.Semantic proximity Read ↗

Notch signaling maintains a progenitor-like subclass of hepatocellular carcinomaSemantic proximity Read ↗

Hepatocellular carcinoma in the context of non-alcoholic steatohepatitis (NASH): recent advances in the pathogenic mechanisms.Semantic proximity Read ↗

Oncogenic role of the Notch pathway in primary liver cancerSemantic proximity Read ↗

Hepatocellular Adenomas: Morphology and Genomics.Semantic proximity Read ↗

AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.Semantic proximity Read ↗

Alcohol-Associated HepatocarcinogenesisSemantic proximity Read ↗

Role of the Notch signaling in cholangiocarcinomaSemantic proximity Read ↗

Molecular Pathology of Hepatic Neoplasms: Classification and Clinical SignificanceSemantic proximity Read ↗

Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.Semantic proximity Read ↗

Notch Signaling Regulation in HCC: From Hepatitis Virus to Non-Coding RNAsSemantic proximity Read ↗

Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.