Article

Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

2024-12-17

Abstract excerpt

Hepatocellular carcinomas (HCCs) constitute one of the few cancer indications for which mortality rates continue to rise. While Notch signaling dictates a key progenitor lineage choice during development, its role in HCC has remained controversial. Using therapeutic antibodies targeting Notch ligands and receptors to screen over 40 patient-derived xenograft models, we here identify progenitor-like HCCs that crucia...

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Literature Corpus work: 15ae406f-d978-5229-9b61-c702b6e407ec
DOI: 10.1101/2024.12.13.628320

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