Article
2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair.
DNA repair - 2 Jan 2005
Hoogervorst Esther M, van Oostrom Conny Th M, Beems Rudolf B, van Benthem Jan, van den Berg Jolanda, van Kreijl Coen F, Vos Joseph G, de Vries Annemieke, van Steeg Harry
Abstract excerpt
The nucleotide excision repair (NER) pathway comprises two sub-pathways, transcription coupled repair (TCR) and global genome repair (GGR). To establish the importance of these separate sub-pathways in tumor suppression, we exposed mice deficient for either TCR (Csb), GGR (Xpc) or both (Xpa) to 300 ppm 2-acetylaminofluorene (in feed, ad libitum) in a unique comparative exposure experiment. We found that cancer...
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