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Article

Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse.

PloS one - 1 Jan 2012

Dillon Lloye M, Hida Aline, Garcia Sofia, Prolla Tomas A, Moraes Carlos T

Abstract excerpt

Pharmacological agents, such as bezafibrate, that activate peroxisome proliferator-activated receptors (PPARs) and PPAR γ coactivator-1α (PGC-1α) pathways have been shown to improve mitochondrial function and energy metabolism. The mitochondrial DNA (mtDNA) mutator mouse is a mouse model of aging that harbors a proofreading-deficient mtDNA polymerase γ. These mice develop many features of premature aging...

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PMID: 22962610
DOI: 10.1371/journal.pone.0044335
PMCID: PMC3433471

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PGC

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