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Article

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome

2025-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Suppression of insulin-like growth factor-1 (IGF-1) signaling extends mammalian lifespan and protects against a range of age-related diseases. Surprisingly though, we found that reduced IGF-1 signaling fails to extend the lifespan of mitochondrial mutator mice. Accordingly, most of the longevity pathways that are normally initiated by IGF-1 suppression were either blocked or blunted in the mutat...

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Identifiers and source

Literature Corpus work
30fa897b-e218-565f-8564-e8eb9ebb3bf3
DOI
10.1101/2025.06.03.656903
Open publication

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The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genomeDOI 10.1101/2025.06.03.656903
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