Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice.

Human molecular genetics - 1 Feb 2012

Yatsuga Shuichi, Suomalainen Anu

Abstract excerpt

Mitochondrial dysfunction is an important cause of metabolic disorders of children and adults, with no effective therapy options. Recently, induction of mitochondrial biogenesis, by transgenic overexpression of PGC1-alpha [peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1-alpha], was reported to delay progression of early-onset cytochrome-c-oxidase (COX) deficiency in skeletal muscle of two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Temperature
Share to Fibroblast Growth Factors
Share to Hepatomegaly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondrial Myopathies

Share to Muscle Fibers, Skeletal

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Peroxisome Proliferator-Activated Receptors

Share to Weight Loss

Source

Identifiers

PMID: 22012983
DOI: 10.1093/hmg/ddr482

Genes

COX10
FGF21
SURF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice.PMID 22012983Read ↗

Pathogenesis and treatment of mitochondrial myopathies: recent advances.Semantic proximity Read ↗

Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse.Semantic proximity Read ↗

Ketogenic diet slows down mitochondrial myopathy progression in mice.Semantic proximity Read ↗

Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone.Semantic proximity Read ↗

Genetic basis for correction of very-long-chain acyl-coenzyme A dehydrogenase deficiency by bezafibrate in patient fibroblasts: toward a genotype-based therapy.Semantic proximity Read ↗

Clinical characterization and molecular mechanisms of statin myopathy.Semantic proximity Read ↗

Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.Semantic proximity Read ↗

Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts.Semantic proximity Read ↗

Mitochondrial myopathies: developments in treatment.Semantic proximity Read ↗

PGC-1β prevents statin-associated myotoxicity in oxidative skeletal muscleSemantic proximity Read ↗

Current issues regarding treatment of mitochondrial fatty acid oxidation disorders.Semantic proximity Read ↗

Constitutive knockout of Surf1 is associated with high embryonic lethality, mitochondrial disease and cytochrome c oxidase deficiency in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.