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Article

Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.

Science advances - 1 May 2021

Lei Yuanjiu, Guerra Martinez Camila, Torres-Odio Sylvia, Bell Samantha L, Birdwell Christine E, Bryant Joshua D, Tong Carl W, Watson Robert O, West Laura Ciaccia, West A Phillip

Abstract excerpt

Mitochondrial dysfunction is a key driver of inflammatory responses in human disease. However, it remains unclear whether alterations in mitochondria-innate immune cross-talk contribute to the pathobiology of mitochondrial disorders and aging. Using the polymerase gamma (POLG) mutator model of mitochondrial DNA instability, we report that aberrant activation of the type I interferon (IFN-I) innate immune axis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34039599
DOI: 10.1126/sciadv.abe7548
PMCID: PMC8153723

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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