Article
The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome.
Science advances - 3 Apr 2026
Shemtov Sarah J, McGann Eric, Carrillo Lucy, Lee Sangmin, Anson Herbert, Hwang Eric, Chung Claire S, Weinert Jaye L, Anagnostou Maria-Eleni, Lai Guan-Ju D, Verheijen Bert M, Wan Junxiang, Vorobyova Ivetta, Sanchez-Contreras Monica, Conover Cheryl A, Thorwald Max A, Cohen Pinchas, Kennedy Scott R, Gout Jean-François, Haroon Suraiya, Vermulst Marc
Abstract excerpt
Suppression of insulin-like growth factor-1 (IGF-1) signaling extends mammalian life span and protects against a range of age-related diseases. Unexpectedly, we found that reduced IGF-1 signaling fails to extend the life span of mitochondrial mutator mice. Most of the longevity pathways that are normally initiated by IGF-1 suppression were either blocked or blunted in the mutator mice. These observations suggest...
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