Article
Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.
Aging - 15 Feb 2017
Shabalina Irina G, Vyssokikh Mikhail Yu, Gibanova Natalia, Csikasz Robert I, Edgar Daniel, Hallden-Waldemarson Anne, Rozhdestvenskaya Zinaida, Bakeeva Lora E, Vays Valeria B, Pustovidko Antonina V, Skulachev Maxim V, Cannon Barbara, Skulachev Vladimir P, Nedergaard Jan
Abstract excerpt
MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of ≈100 days with the mitochondria-targeted antioxidant SkQ1 showed a delayed appearance of traits of aging such as kyphosis, alopecia, lowering of body temperature, body weight loss, as well as ameliorated heart, kidney and liver pathologies. These effects of SkQ1 are suggested to be related to an alleviation...
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