Article
Mutational analysis of the human immunodeficiency virus type 2 (HIV-2) genome in relation to HIV-1 and simian immunodeficiency virus SIV (AGM).
Journal of virology - 1 Feb 1990
Shibata R, Miura T, Hayami M, Ogawa K, Sakai H, Kiyomasu T, Ishimoto A, Adachi A
Abstract excerpt
We constructed an infectious molecular clone of the human immunodeficiency virus type 2 (HIV-2) and generated nine frameshift mutants corresponding to nine open reading frames identified so far. Three structural (gag, pol, env) and two regulative (tat, rev) gene mutants were not infectious, where...
Topics
- Blotting, Northern
- Blotting, Western
- Cell Line
- Chloramphenicol O-Acetyltransferase
- DNA, Viral
- Genes, Viral
- HIV-1
- HIV-2
- Humans
- Leukemia
- Mutation
- Plasmids
- RNA, Viral
- Restriction Mapping
- Simian Immunodeficiency Virus