Construction and characterization of an infectious DNA clone and of mutants of simian immunodeficiency virus isolated from the African green monkey.

doi:10.1128/JVI.64.1.307-312.1990

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Article

Construction and characterization of an infectious DNA clone and of mutants of simian immunodeficiency virus isolated from the African green monkey.

Journal of virology - 1 Jan 1990

Shibata R, Miura T, Hayami M, Sakai H, Ogawa K, Kiyomasu T, Ishimoto A, Adachi A

Abstract excerpt

We constructed a full-length molecular clone of simian immunodeficiency virus from an African green monkey. Upon transfection, this clone directed the production of virus particles cytopathic and infectious to human CD4+ leukemia cell lines. Mutations were introduced by recombinant DNA techniques...

Topics

Animals
CD4 Antigens
Cell Line
Cercopithecus
Chlorocebus aethiops
Cloning, Molecular
DNA, Viral
Genes, Regulator
Genes, Viral
Humans
Mutation
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Simian Immunodeficiency Virus

Transcription, Genetic

Transcriptional Activation

Transfection

Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 2293665
DOI: 10.1128/JVI.64.1.307-312.1990
PMCID: PMC249103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2293665-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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