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Article

Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants.

Journal of virology - 1 Jun 1995

Reddy T R, Kraus G, Yamada O, Looney D J, Suhasini M, Wong-Staal F

Abstract excerpt

Virion infectivity factor (vif), a gene found in all lentiviruses, plays an essential role in virus replication in certain target cells. We examined the replication competence of the human immunodeficiency virus type 2 (HIV-2) vif mutant in different T-cell lines and primary cells in comparison with that of the HIV-1 vif mutant. Both mutant viruses were unable to replicate in peripheral blood-derived mononuclear...

Topics

Amino Acid Sequence
Base Sequence
Cell Line
DNA Primers
Genes, vif
Genetic Complementation Test
HIV-1
HIV-2
Humans
Molecular Sequence Data
Mutation
Sequence Homology, Amino Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

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Identifiers

PMID: 7745702
DOI: 10.1128/JVI.69.6.3549-3553.1995
PMCID: PMC189069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7745702-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants.PMID 7745702Read ↗

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