Article
Biological characterization of human immunodeficiency virus type 1 and type 2 mutants in human peripheral blood mononuclear cells.
Archives of virology - 1 Jan 1992
Akari H, Sakuragi J, Takebe Y, Tomonaga K, Kawamura M, Fukasawa M, Miura T, Shinjo T, Hayami M
Abstract excerpt
Mutants of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), which have been shown to be infectious in established cell lines, were tested for ability to replicate and induce syncytium formation in human peripheral blood mononuclear cells (PBMC). The vpu mutant of HIV-1 showed depre...
Topics
- Cells, Cultured
- DNA, Recombinant
- Genes, Regulator
- Genes, Viral
- Genes, nef
- Giant Cells
- HIV Long Terminal Repeat
- HIV-1
- HIV-2
- Humans
- Leukocytes, Mononuclear
- Mutation
- Phenotype
- Transfection
- Tumor Cells, Cultured
- Virus Replication