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Article

Mutational analysis of simian immunodeficiency virus from African green monkeys and human immunodeficiency virus type 2.

Journal of medical primatology - 1 Jan 1990

Shibata R, Adachi A, Sakai H, Ishimoto A, Miura T, Hayami M

Abstract excerpt

We constructed ten mutants of simian immunodeficiency virus isolated from African green monkey (SIVAGM), and nine mutants of human immunodeficiency virus type 2 (HIV-2) in vitro. Their infectivity, cytopathogenicity, transactivation potential, virus RNA, and protein synthesis were examined by transfection and infection experiments. Mutations in three structural (gag, pol, env) and two regulator (tat, rev) genes...

Topics

Animals
Cell Line
Chlorocebus aethiops
Genes, Viral
Genes, rev
Genes, tat
HIV-1
HIV-2
Humans
Mutation
Simian Immunodeficiency Virus
Transcriptional Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Tumor Cells, Cultured

Virus Replication

Source

Identifiers

PMID: 2231682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2231682-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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