Article
Suppression of HIV replication by dominant negative mutants of HIV-1 (review).
International journal of molecular medicine - 1 Sept 1998
Inubushi R, Shimano R, Oshima Y, Yoshida K, Kawamura M, Adachi A
Abstract excerpt
Various gag mutants of human immunodeficiency virus type 1 (HIV-1) generated in vitro were evaluated for their potentials to suppress the replication of wild-type (wt) virus. A single-round of wt virus replication in the presence of various mutant proteins was quantitatively monitored by transfection and infection experiments. Out of 38 mutants examined, 15 were demonstrated to interfere with the replication of...
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