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Article

Vaccinia virus morphogenesis is blocked by temperature-sensitive mutations in the F10 gene, which encodes protein kinase 2.

Journal of virology - 1 Oct 1995

Wang S, Shuman S

Abstract excerpt

Four previously isolated temperature-sensitive (ts) mutants of vaccinia virus WR (ts28, ts54, ts61, and ts15) composing a single complementation group have been mapped by marker rescue to the F10 open reading frame located within the genomic HindIII F DNA fragment. Sequencing of the F10 gene from wild-type and mutant viruses revealed single-amino-acid substitutions in the F10 polypeptide responsible for...

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Identifiers

PMID: 7666539
DOI: 10.1128/JVI.69.10.6376-6388.1995
PMCID: PMC189537

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