Vaccinia virus morphogenesis is blocked by temperature-sensitive mutations in the F10 gene, which encodes protein kinase 2.

doi:10.1128/JVI.69.10.6376-6388.1995

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Article

Vaccinia virus morphogenesis is blocked by temperature-sensitive mutations in the F10 gene, which encodes protein kinase 2.

Journal of virology - 1 Oct 1995

Wang S, Shuman S

Abstract excerpt

Four previously isolated temperature-sensitive (ts) mutants of vaccinia virus WR (ts28, ts54, ts61, and ts15) composing a single complementation group have been mapped by marker rescue to the F10 open reading frame located within the genomic HindIII F DNA fragment. Sequencing of the F10 gene from wild-type and mutant viruses revealed single-amino-acid substitutions in the F10 polypeptide responsible for...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cloning, Molecular
DNA Primers
Deoxyribonuclease HindIII
Genes, Viral
Genetic Complementation Test
Histidine
Hot Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Microscopy, Electron

Molecular Sequence Data

Morphogenesis

Mutation

Open Reading Frames

Plasmids

Source

Open in PubMed Open full text

Identifiers

PMID: 7666539
DOI: 10.1128/JVI.69.10.6376-6388.1995
PMCID: PMC189537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7666539-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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