Article
The vaccinia virus-encoded uracil DNA glycosylase has an essential role in viral DNA replication.
Virology - 1 Feb 1994
Millns A K, Carpenter M S, DeLange A M
Abstract excerpt
The vaccinia virus conditional-lethal temperature-sensitive (ts) mutant ts4149 is, at the nonpermissive temperature, severely impaired in its ability to replicate its DNA genome. Compared to wild type, the amount of replication is suppressed by several orders of magnitude, and the little DNA that...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cells, Cultured
- DNA Glycosylases
- DNA Replication
- DNA, Viral
- Molecular Sequence Data
- Mutation
- N-Glycosyl Hydrolases
- Open Reading Frames
- Protein Conformation
- Restriction Mapping
- Uracil-DNA Glycosidase
- Vaccinia virus
- Virus Replication