Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The vaccinia virus-encoded uracil DNA glycosylase has an essential role in viral DNA replication.

Virology - 1 Feb 1994

Millns A K, Carpenter M S, DeLange A M

Abstract excerpt

The vaccinia virus conditional-lethal temperature-sensitive (ts) mutant ts4149 is, at the nonpermissive temperature, severely impaired in its ability to replicate its DNA genome. Compared to wild type, the amount of replication is suppressed by several orders of magnitude, and the little DNA that is replicated is not converted to mature linear genomes. We have demonstrated that this "DNA-" phenotype is not the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Viral

Share to Molecular Sequence Data

Share to Mutation

Share to Protein Conformation

Share to Restriction Mapping

Source

Identifiers

PMID: 8291232
DOI: 10.1006/viro.1994.1061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The vaccinia virus-encoded uracil DNA glycosylase has an essential role in viral DNA replication.PMID 8291232Read ↗

Identification of a temperature-sensitive mutant of vaccinia virus defective in late but not intermediate gene expression.Semantic proximity Read ↗

Vaccinia virus DNA replication: a short review.Semantic proximity Read ↗

Temperature-sensitive vaccinia virus mutants identify a gene with an essential role in viral replication.Semantic proximity Read ↗

Characterization of vaccinia virus DNA replication mutants with lesions in the D5 gene.Semantic proximity Read ↗

Temperature-sensitive mutations in the vaccinia virus H4 gene encoding a component of the virion RNA polymerase.Semantic proximity Read ↗

A temperature-sensitive lesion in the small subunit of the vaccinia virus-encoded mRNA capping enzyme causes a defect in viral telomere resolution.Semantic proximity Read ↗

A temperature-sensitive mutation of the vaccinia virus E11 gene encoding a 15-kDa virion component.Semantic proximity Read ↗

Vaccinia virus uracil DNA glycosylase has an essential role in DNA synthesis that is independent of its glycosylase activity: catalytic site mutations reduce virulence but not virus replication in cultured cells.Semantic proximity Read ↗

Vaccinia virus morphogenesis is blocked by a temperature-sensitive mutation in the I7 gene that encodes a virion component.Semantic proximity Read ↗

Role of vaccinia virus A20R protein in DNA replication: construction and characterization of temperature-sensitive mutants.Semantic proximity Read ↗

Identification of the point mutations in two vaccinia virus nucleoside triphosphate phosphohydrolase I temperature-sensitive mutants and role of this DNA-dependent ATPase enzyme in virus gene expression.Semantic proximity Read ↗

Structure and expression of the vaccinia virus gene which prevents virus-induced breakdown of RNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.