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Article

Characterization of vaccinia virus DNA replication mutants with lesions in the D5 gene.

Chromosoma - 1 Jan 1992

Evans E, Traktman P

Abstract excerpt

The vaccinia virus D5 gene encodes a 90 kDa early protein that is essential for viral DNA replication. In this report we map and explore the phenotypes of the temperature sensitive mutants bearing lesions in this gene: ts17, ts24, ts69 (WR strain) and ts6389 (IHD strain). Viral DNA synthesis was virtually undetectable during non-permissive infections performed with ts17, and incorporation of 3H-thymidine ceased...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosome Mapping
DNA Mutational Analysis
DNA Replication
Genetic Markers
Molecular Sequence Data
Mutation
Recombination, Genetic
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vaccinia virus

Viral Proteins

Virus Replication

Source

Identifiers

PMID: 1291243
DOI: 10.1007/BF02451789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1291243-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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