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Article

Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture?

American journal of human genetics - 7 Sept 2012

Elbein Steven C, Gamazon Eric R, Das Swapan K, Rasouli Neda, Kern Philip A, Cox Nancy J

Abstract excerpt

To date, 68 loci have been associated with type 2 diabetes (T2D) or glucose homeostasis traits. We report here the results of experiments aimed at functionally characterizing the SNPs replicated for T2D and glucose traits. We sought to determine whether these loci were associated with transcript levels in adipose, muscle, liver, lymphocytes, and pancreatic β-cells. We found an excess of trans, rather than cis,...

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Identifiers

PMID: 22958899
DOI: 10.1016/j.ajhg.2012.08.002
PMCID: PMC3512001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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