Article
Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations.
Diabetes - 1 Dec 2016
Chen Brian H, Hivert Marie-France, Peters Marjolein J, Pilling Luke C, Hogan John D, Pham Lisa M, Harries Lorna W, Fox Caroline S, Bandinelli Stefania, Dehghan Abbas, Hernandez Dena G, Hofman Albert, Hong Jaeyoung, Joehanes Roby, Johnson Andrew D, Munson Peter J, Rybin Denis V, Singleton Andrew B, Uitterlinden André G, Ying Saixia, Melzer David, Levy Daniel, van Meurs Joyce B J, Ferrucci Luigi, Florez Jose C, Dupuis Josée, Meigs James B, Kolaczyk Eric D
Abstract excerpt
Genome-wide association studies (GWAS) have successfully identified genetic loci associated with glycemic traits. However, characterizing the functional significance of these loci has proven challenging. We sought to gain insights into the regulation of fasting insulin and fasting glucose through the use of gene expression microarray data from peripheral blood samples of participants without diabetes in the...
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