Article
Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity.
Human genetics - 1 Aug 2016
Sajuthi Satria P, Sharma Neeraj K, Chou Jeff W, Palmer Nicholette D, McWilliams David R, Beal John, Comeau Mary E, Ma Lijun, Calles-Escandon Jorge, Demons Jamehl, Rogers Samantha, Cherry Kristina, Menon Lata, Kouba Ethel, Davis Donna, Burris Marcie, Byerly Sara J, Ng Maggie C Y, Maruthur Nisa M, Patel Sanjay R, Bielak Lawrence F, Lange Leslie A, Guo Xiuqing, Sale Michèle M, Chan Kei Hang K, Monda Keri L, Chen Gary K, Taylor Kira, Palmer Cameron, Edwards Todd L, North Kari E, Haiman Christopher A, Bowden Donald W, Freedman Barry I, Langefeld Carl D, Das Swapan K
Abstract excerpt
Relative to European Americans, type 2 diabetes (T2D) is more prevalent in African Americans (AAs). Genetic variation may modulate transcript abundance in insulin-responsive tissues and contribute to risk; yet, published studies identifying expression quantitative trait loci (eQTLs) in African ancestry populations are restricted to blood cells. This study aims to develop a map of genetically regulated transcripts...
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