Article
Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.
The Journal of clinical endocrinology and metabolism - 1 Feb 2011
Sharma Neeraj K, Langberg Kurt A, Mondal Ashis K, Elbein Steven C, Das Swapan K
Abstract excerpt
CONTEXT: Genome-wide association scans (GWAS) have identified novel single nucleotide polymorphisms (SNPs) that increase T2D susceptibility and indicated the role of nearby genes in T2D pathogenesis. OBJECTIVE: We hypothesized that T2D-associated SNPs act as cis-regulators of nearby genes in human tissues and that expression of these transcripts may correlate with metabolic traits, including insulin sensitivity...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.