Article
Development of a diphtheria toxin mutant conjugate directed against antigen-specific B cells expressing high affinity surface Ig.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1990
Marsh J W, Klinman D M
Abstract excerpt
Modification of a mutant diphtheria toxin, possessing reduced binding capacity, with TNP groups resulted in an Ag-toxin conjugate capable of eliminating TNP-specific B cells. Previous experimental approaches to the elimination of Ag-specific B cells have involved the conjugation of Ag to holoricin molecules or ricin A chain. Holoricin conjugates possess efficacy, but display high nonspecific toxicity. A chain...
Topics
- Animals
- B-Lymphocytes
- Diphtheria Toxin
- Immunotoxins
- In Vitro Techniques
- Mice
- Mutation
- Protein Biosynthesis
- Receptors, Antigen, B-Cell
- Trinitrobenzenes