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Article

Development of a diphtheria toxin mutant conjugate directed against antigen-specific B cells expressing high affinity surface Ig.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1990

Marsh J W, Klinman D M

Abstract excerpt

Modification of a mutant diphtheria toxin, possessing reduced binding capacity, with TNP groups resulted in an Ag-toxin conjugate capable of eliminating TNP-specific B cells. Previous experimental approaches to the elimination of Ag-specific B cells have involved the conjugation of Ag to holoricin molecules or ricin A chain. Holoricin conjugates possess efficacy, but display high nonspecific toxicity. A chain...

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PMID: 2295812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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