Mutations in diphtheria toxin to improve immunotoxin selectivity and understand toxin entry into cells.

Abstract excerpt

Diphtheria toxin can be used to selectively kill target cells by coupling it to cell-type-specific binding moieties such as monoclonal antibodies. These reagents have important potential in treating diseases, selectively ablating cell populations in experimental systems and for understanding how...

Topics

• Amino Acid Sequence
• Animals
• Diphtheria Toxin
• Immunotoxins
• Molecular Sequence Data
• Mutation