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Article

Mutations in diphtheria toxin to improve immunotoxin selectivity and understand toxin entry into cells.

Seminars in cell biology - 1 Feb 1991

Youle R J

Abstract excerpt

Diphtheria toxin can be used to selectively kill target cells by coupling it to cell-type-specific binding moieties such as monoclonal antibodies. These reagents have important potential in treating diseases, selectively ablating cell populations in experimental systems and for understanding how proteins cross membranes. Point mutations and deletions in the diphtheria toxin gene have been used to identify and...

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PMID: 1954342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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