A variant of exotoxin A that forms potent and specific chemically conjugated immunotoxins.

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Article

A variant of exotoxin A that forms potent and specific chemically conjugated immunotoxins.

The Journal of biological chemistry - 5 May 1993

Chaudry G J, Fulton R J, Draper R K

Abstract excerpt

To introduce a free sulfhydryl into Pseudomonas aeruginosa exotoxin A (ETA), methionine 161 in domain I of the toxin was changed to cysteine by site-directed mutagenesis. The free sulfhydryl provides a convenient site for covalent attachment of ETA to other proteins in the production of chimeric...

Topics

ADP Ribose Transferases
Amino Acid Sequence
Animals
Antibodies, Monoclonal
Bacterial Toxins
Base Sequence
Carrier Proteins
Cell Survival
Cloning, Molecular
Cysteine
Escherichia coli
Exotoxins
Genetic Variation
Humans
Immunotoxins
L Cells
Methionine
Mice

Source

Open in PubMed

Identifiers

PMID: 8486636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8486636-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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