Article
Cytotoxic activity of a tumor protease-activated pore-forming toxin.
Bioconjugate chemistry - 1 Jan 2000
Potrich C, Tomazzolli R, Dalla Serra M, Anderluh G, Malovrh P, Macek P, Menestrina G, Tejuca M
Abstract excerpt
Equinatoxin II is a pore forming toxin produced by the sea anemone Actinia equina. It is able to kill very unspecifically most cell types by the membrane-perturbing action of an amphiphilic alpha-helix located at its N-terminal. A normally active N-terminal mutant, containing one single cys in the amphiphilic alpha-helix, becomes totally inactive when it is bound to avidin via a biotinylated linker. By choosing,...
Topics
- Animals
- Antineoplastic Agents
- Breast Neoplasms
- Cathepsin B
- Cell Line, Tumor
- Cnidarian Venoms
- Cross-Linking Reagents
- Cytotoxins
- Drug Delivery Systems
- Female
- Fibrosarcoma
- Humans
- Male
- Matrix Metalloproteinases
- Mutation
- Neoplasm Proteins
- Peptides
- Prodrugs