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Article

Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome.

PloS one - 1 Jan 2012

Sato Naoko, Suzuki Naoki, Sasaki Ayaka, Aizawa Emiko, Obayashi Takeshi, Kanazawa Motoyori, Mizuno Tomoko, Kano Michiko, Aoki Masashi, Fukudo Shin

Abstract excerpt

BACKGROUND: Corticotropin-releasing hormone (CRH) acts mainly via the CRH receptor 1 (CRH-R1) and plays a crucial role in the stress-induced pathophysiology of irritable bowel syndrome (IBS). Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is lacking. We tested the hypothesis that genetic...

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Identifiers

PMID: 22957021
DOI: 10.1371/journal.pone.0042450
PMCID: PMC3434156

Genes

CRH
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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